反应详情

A solution of piperidine in dimethylformamide 50% (1.92 mL) was added to Fmoc-Val-Pro-doxorubicin (F) (29.7 mg, 0.03 mmol) and the reaction mixture was stirred at room temperature for 1 minute (the reaction colour changes form red to purple). Then, the reaction mixture was evaporated to dryness under reduced pressure and the residue thus obtained was purified by reverse phase chromatography with water/acetonitrile (70:1) to give the deprotected compound G (50% yield)

1. customform red to purple)
2. customThen, the reaction mixture was evaporated to dryness under reduced pressure
3. customthe residue thus obtained
4. customwas purified by reverse phase chromatography with water/acetonitrile (70:1)