反应详情

温度

0 °C

A 100 mL round bottom flask equipped with magnetic stir bar was charged with 0.42 mL (1.05 eq) N-methyl-piperazine, 1 mL NEt3 and 20 mL CH2Cl2. The solution was cooled to 0° C. and 1.0 g of benzyl 3-chlorosulfonyl-2(R)-methylpropionate from Example 3 in 5 mL CH2Cl2 was added. After 1 hour reaction was concentrated in vacuo. The residue was partioned between EA/H2O and the organic phase was washed with saturated aqueous bicarb., brine, dried, and concentrated in vacuo to yield benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate which was used without further purification.

1. customA 100 mL round bottom flask equipped with magnetic stir bar
2. customAfter 1 hour reaction
3. concentrationwas concentrated in vacuo
4. washthe organic phase was washed with saturated aqueous bicarb
5. dry with material, brine, dried
6. concentrationconcentrated in vacuo