Cesium carbonate → 8-(2-Amino-1,1-dimethylethylsulfanyl)-3-methyl-7-(3-methylbut-2-enyl)-3,7-dihydropurine-2,6-dione

HRID 882878Notes

Reaction equation

HRID 882878 reaction equation
Br[C:2]1[N:10]([CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[C:9]2[C:8](=[O:16])[NH:7][C:6](=[O:17])[N:5]([CH3:18])[C:4]=2[N:3]=1.Cl.[NH2:20][CH2:21][C:22]([CH3:25])([SH:24])[CH3:23].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[NH2:20][CH2:21][C:22]([S:24][C:2]1[N:10]([CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[C:9]2[C:8](=[O:16])[NH:7][C:6](=[O:17])[N:5]([CH3:18])[C:4]=2[N:3]=1)([CH3:25])[CH3:23]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 34353313-Methyl-7-(3-methyl-2-buten-1-yl)-8-bromo-xanthineHCID 130491041-Amino-2-methyl-2-propanethiol hydrochloride

Product 1

HCID 694485498-(2-Amino-1,1-dimethylethylsulfanyl)-3-methyl-7-(3-methylbut-2-enyl)-3,7-dihydropurine-2,6-dione

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 80 mg of 8-bromo-3-methyl-7-(3-methylbut-2-enyl)-3,7-dihydropurine-2,6-dione, 90 mg of 1-amino-2-methyl-2-propanethiol hydrochloride, 2 ml of DMF and 200 mg of cesium carbonate was stirred at 70° C. for 5 hours.

Sources & evidence

ORD record
ord-ee23233cf0134f189ea3cbffeabe7ef6
Source dataset
uspto-grants-2012_08
Patent number
US08236810B2

Reaction notes

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