Hydrochloric Acid → HCID 67027822, compound

HRID 882931Notes

Reaction equation

HRID 882931 reaction equation
C[O:2][C:3](=[O:27])[CH2:4][CH:5]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([S:20](=[O:26])(=[O:25])[N:21]=[C:22]([NH2:24])[NH2:23])[CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Li+].[OH-].Cl>CO.O>[NH2:24][C:22](=[N:21][S:20]([C:14]1[CH:13]=[C:12]([CH:5]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:4][C:3]([OH:27])=[O:2])[CH:17]=[CH:16][C:15]=1[O:18][CH3:19])(=[O:25])=[O:26])[NH2:23]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67028159HCID 67028159, compound

Product 1

HCID 67027822HCID 67027822, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 3-[3-(diaminomethylene-sulfamoyl)-4-methoxy-phenyl]-3-phenyl-propionic acid methyl ester (400 mg, 1.02 mmol) in a mixture of MeOH and water (30 mL of 1:1 solution) is added LiOH (73 mg, 3.06 mmol). The reaction mixture is stirred at RT overnight. 1 M aqueous HCl is added to neutralise the reaction mixture. The resulting solid is collected by filtration and dried under vacuum to afford the title compound that is used without further purification.

Workup

  1. filtrationThe resulting solid is collected by filtration
  2. customdried under vacuum

Sources & evidence

ORD record
ord-eaf67288fc0549cd93ab70d105b767f6
Source dataset
uspto-grants-2012_08
Patent number
US08236808B2

Reaction notes

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