反应详情

温度

60 °C

Dimethylformamide (1 ml) was added to 2-(4-amino-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl)-N-methylacetamide trifluoroacetate (28 mg), 3-chloro-2-(chloromethyl)-4-methoxy-5-methylpyridine hydrochloride (36 mg), and potassium carbonate (69 mg). The resulting mixture was stirred at 60° C. for 2.5 hours. Thereafter, the insoluble matter was removed by filtration, and the solvent was then distilled away in a nitrogen stream. The resulting residue was dissolved in dimethyl sulfoxide (1 ml), and it was then purified by preparatory reverse-phase HPLC. The solvent was distilled away under reduced pressure, so as to obtain the title compound (27.0 mg) as a solid.

1. customThereafter, the insoluble matter was removed by filtration
2. distillationthe solvent was then distilled away in a nitrogen stream
3. dissolutionThe resulting residue was dissolved in dimethyl sulfoxide (1 ml)
4. customit was then purified by preparatory reverse-phase HPLC
5. distillationThe solvent was distilled away under reduced pressure