反应详情

The product from Step C (2.4 g, 11.0 mmol) was dissolved in 2-methoxyethyl ether (20 mL) and refluxed for 24 hours. The reaction was cooled to room temperature and basified to pH 9 with concentrated ammonium hydroxide. The mixture was extracted once with diethyl ether and set aside. The aqueous layer was acidified with concentrated hydrochloride acid and extracted four times with diethyl ether. The extract were combined and dried over sodium sulfate, filtered and concentrated to give 4-thiophen-3-yl-butyric acid (1.8 g, 95%) as an oil.

1. temperaturerefluxed for 24 hours
2. extractionThe mixture was extracted once with diethyl ether
3. extractionextracted four times with diethyl ether
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated