反应详情

A solution of 4-Chloro-3-nitro-phenol (2.0 g, 11.52 mmol), 4-hydroxythiophenol (1.45 g, 11.52 mmol) and cesium carbonate (11.26 g, 34.56 mmol) in N,N-dimethylformamide (25 mL) was heated to 100° C. for 4 hours. After cooling to room temperature, 1N aqueous Hydrochloric acid (150 mL) was added and the resultant solution extracted with ethyl acetate (2×100 mL), the combined extracts dried over magnesium sulfate, filtered and concentrated under vacuum to provide the crude title compound which was purified by chromatography on silica gel using hexanes/ethyl acetate as eluent to obtain the title product as a bright orange solid (1.35 g, 45%).

1. extractionthe resultant solution extracted with ethyl acetate (2×100 mL)
2. dry with materialthe combined extracts dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated under vacuum
5. customto provide the crude title compound which
6. customwas purified by chromatography on silica gel