Potassium Carbonate → HCID 67040614, compound

HRID 883873Notes

Reaction equation

HRID 883873 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)=[O:10])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17].C([O-])([O-])=O.[K+].[K+].[SH:25][C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1>CN(C=O)C.O>[OH:32][C:29]1[CH:30]=[CH:31][C:26]([S:25][C:2]2[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]3[O:12][CH:13]=[CH:14][CH:15]=3)=[O:10])=[CH:4][C:3]=2[N+:16]([O-:18])=[O:17])=[CH:27][CH:28]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 2401474-MercaptophenolHCID 789035HCID 789035, compound

Product 1

HCID 67040614HCID 67040614, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

The product of Example 18a (1.00 g, 2.89 mmol) was dissolved in DMF to which K2CO3 (801 mg, 5.79 mmol), and 4-mercapto-phenol (366 mg, 2.89 mmol) were added. The reaction mixture was then heated to 80° C. for 2 hrs. At this point the reaction mixture was cooled to room temperature and diluted with water which was then extracted with ethyl acetate to isolate the desired compound (1.00 g, 99%).

Workup

  1. additionwere added
  2. temperatureAt this point the reaction mixture was cooled to room temperature
  3. extractionwas then extracted with ethyl acetate

Sources & evidence

ORD record
ord-cd4f03d18b7341e08d888d808e2af7cd
Source dataset
uspto-grants-2012_08
Patent number
US08236950B2

Reaction notes

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