反应详情

A mixture of 1,4-dichloro-2-nitrobenzene (20.0 g, 104.2 mmol) and methyl 4-hydroxybenzoate (15.85 g, 104.2 mmol) in 150 mL of EtOH was treated with Na2CO3 and heated overnight under reflux. Cooled to room temperature and quenched with water. Extracted with EtOAc. Dried over MgSO4′ filtered and concentrated under vacuum giving the title compound, which was purified by silica gel column chromatography eluting with 10% EtOAc/hexane giving the title compound as a yellow solid (29.6 g, 92%).

1. temperatureheated overnight
2. temperatureunder reflux
3. customquenched with water
4. extractionExtracted with EtOAc
5. dry with materialDried over MgSO4′
6. filtrationfiltered
7. concentrationconcentrated under vacuum