反应详情

The compound from Example 34a (29.6 g, 96.2 mmol) in 200 mL of MeOH was treated with aqueous LiOH (1 M) and heated under reflux for 1 hour. Cooled to room temperature and acidified with aqueous HCl (1 M). Precipitate was filtered, washed with H2O and air-dried giving the title compound as a yellow solid (28.2 g, 100%).

1. temperatureheated
2. temperatureunder reflux for 1 hour
3. filtrationPrecipitate was filtered
4. washwashed with H2O
5. customair-dried