2-Aminothiazole → 4-chloro-3-nitro-N-(1,3-thiazol-2-yl)benzamide

HRID 883949Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[S:14]1[CH:18]=[CH:17][N:16]=[C:15]1[NH2:19]>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:19][C:15]2[S:14][CH:18]=[CH:17][N:16]=2)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 1234774-Chloro-3-nitrobenzoyl chloride

Product 1

HCID 7492184-chloro-3-nitro-N-(1,3-thiazol-2-yl)benzamide

Procedure

A mixture of 4-chloro-3-nitrobenzoyl chloride was reacted with Thiazol-2-ylamine to produce 4-Chloro-3-nitro-N-thiazol-2-yl-benzamide according to the procedure of Example 49A, which was treated sequentially using the procedures from Examples 53A and 53B to provide the title product.

Sources & evidence

ORD record: ord-3a0b6da55567479aa4df25cdfe625bec
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08236950B2

Reaction notes

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