反应详情

To a solution of 4 (2.89 g, 6.09 mmol) in MeOH (40 ml) was added 4N HCl in 1,4-dioxane (15.2 ml) under ice cooling, and the mixture was stirred at room temperature for 2 h. A solution of NaHCO3 in H2O was poured into the reaction mixture under ice cooling, and the whole was extracted with AcOEt. The organic layer was washed with brine, dried over Na2SO4, and then concentrated. The residual solid was triturated with AcOEt to give 5 (89%).

1. extractionthe whole was extracted with AcOEt
2. washThe organic layer was washed with brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customThe residual solid was triturated with AcOEt