反应详情

温度

80 °C

To a solution of ethyl 3-(4-hydroxyphenyl)-propionate (6.00 g, 30.9 mmol) in DMF (60 mL) were added 4-fluoronitrobenzene (6.54 g, 46.3 mmol) and potassium carbonate (5.12 g, 37.1 mmol). The resulting reaction solution was stirred for 1 hour at 80° C. To the reaction solution was added water and extracted with ethyl acetate. The resulting ethyl acetate layer was washed with water and then with brine. The ethyl acetate layer was dried over anhydrous magnesium sulfate, evaporated, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1), to thereby yield 9.64 g of the title compound.

1. customThe resulting reaction solution
2. extractionextracted with ethyl acetate
3. washThe resulting ethyl acetate layer was washed with water
4. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
5. customevaporated
6. customthe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1)