Water → HCID 68525632, compound

HRID 884100Notes

Reaction equation

HRID 884100 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:13][CH:12]=2)=[N:8][CH:9]=1)([O-:3])=[O:2].[C:22](=O)([O-])[O-].[K+].[K+].CI.O>CN(C=O)C>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:13][CH:12]=2)=[N:8][CH:9]=1)([O-:3])=[O:2]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 685270993-[4-(5-Nitropyridin-2-ylsulfanyl)phenyl]propionic acid

Product 1

HCID 68525632HCID 68525632, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 3-[4-(5-nitropyridin-2-ylsulfanyl)phenyl]propionic acid (86.0 g, 0.283 mmol) in DMF (1 mL) were added potassium carbonate (59.0 mg, 0.424 mmol) and methyl iodide (0.0260 mL, 0.424 mmol), and the resulting solution was stirred for 1 hour at room temperature. Water was added to the reaction mixture, and then cooled with ice. The precipitated solid matter was collected by filtration, to thereby yield 76.9 mg of the title compound.

Workup

  1. temperaturecooled with ice
  2. filtrationThe precipitated solid matter was collected by filtration

Sources & evidence

ORD record
ord-bc5293eb3fb444edb3227d50bcbd4a6b
Source dataset
uspto-grants-2012_08
Patent number
US08236826B2

Reaction notes

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