Ethanol → HCID 68524463, compound

HRID 884103Notes

Reaction equation

HRID 884103 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([N:19]3[CH2:24][CH2:23][N:22]([CH2:25][C:26]4[CH:34]=[CH:33][C:32]5[O:31][CH2:30][O:29][C:28]=5[CH:27]=4)[CH2:21][CH2:20]3)=[O:18])=[CH:13][CH:12]=2)=[N:8][CH:9]=1)([O-])=O.C(O)C>[Pt].[C].C1COCC1>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]([N:19]3[CH2:20][CH2:21][N:22]([CH2:25][C:26]4[CH:34]=[CH:33][C:32]5[O:31][CH2:30][O:29][C:28]=5[CH:27]=4)[CH2:23][CH2:24]3)=[O:18])=[CH:15][CH:16]=2)=[N:8][CH:9]=1

Participants

5

Reactant 2

HCID 702EthanolHCID 68524464HCID 68524464, compound

Product 1

HCID 68524463HCID 68524463, compound

Reagents, catalysts & solvents 2

HCID 178503042HCID 178503042, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

[4-(5-nitropyridin-2-yloxy)phenyl](4-piperonylpiperazin-1-yl)methanone (0.36 g, 0.78 mmol) was dissolved in a mixed solvent consisting of ethanol (5 mL) and THF (5 mL). To the resulting solution was added 5% platinum-carbon (0.06 g), and stirred at room temperature under a hydrogen atmosphere. Two hours later, the 5% platinum-carbon was removed by filtration, and the solvent was evaporated under reduced pressure, to thereby yield 0.32 g of the title compound.

Workup

  1. customTwo hours later, the 5% platinum-carbon was removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b6c0709dd7ff47c98b7219c97339f4da
Source dataset
uspto-grants-2012_08
Patent number
US08236826B2

Reaction notes

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