反应详情

温度

50 °C

To a solution of 2-(4-chloromethylphenoxy)-5-nitropyridine (12.32 g, 47 mmol) in DMF (120 mL) were added triethylamine (19.4 mL, 140 mmol) and t-butyl piperazine-1-carboxylate 11.27 g, 61 mmol), and the resulting solution was stirred for 3 hours at 50° C. Water was added to the residue, and extracted with ethyl acetate. The ethyl acetate layer was washed with water and brine. The ethyl acetate layer was dried over anhydrous magnesium sulfate, and evaporated. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1), to thereby yield 11.26 g of the title compound.

1. extractionextracted with ethyl acetate
2. washThe ethyl acetate layer was washed with water and brine
3. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
4. customevaporated
5. customThe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1)