反应详情

To [3-(4-bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.40 g, 0.93 mmol) and 2-oxazolidone (0.10 g, 1.14 mmol) in DMF (5 mL) was added sodium hydride (60% in mineral oil; 0.05 g, 1.25 mmol), and the mixture was stirred at room temperature for 30 minutes. After work-up, the crude material was purified by silica gel chromatography (0-50% EtOAc in hexanes). Further purification by preparative HPLC gave the desired product (0.02 g).

1. customAfter work-up, the crude material was purified by silica gel chromatography (0-50% EtOAc in hexanes)
2. customFurther purification by preparative HPLC