Hydrochloric Acid → Methyl 3-Hydroxyphenylacetate

HRID 885246Notes

Reaction equation

HRID 885246 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.Cl.[CH3:13]O>O1CCOCC1>[CH3:13][O:10][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([OH:1])[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 121223'-Hydroxyphenylacetic acid

Product 1

HCID 39129Methyl 3-Hydroxyphenylacetate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-Hydroxyphenylacetic acid (5 g, 32.9 mmol) in MeOH was treated with 4N HCl in 1,4-dioxane (3 mL) at 80° C. for 3 hours. The solution was concentrated to dryness to give the desired product as a yellow oil (5 g).

Workup

  1. concentrationThe solution was concentrated to dryness

Sources & evidence

ORD record
ord-49dc1924f75343daaf1434800ddd59d7
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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