HCID 11948473, compound → HCID 11948474, compound

HRID 885697Notes

Reaction equation

HRID 885697 reaction equation
C([O:5][C:6](=[O:42])[CH2:7][N:8]([CH:21]1[CH2:29][CH2:28][C:27]2[C:23](=[CH:24][N:25]([C:30]3[C:39]4[C:34](=[CH:35][CH:36]=[C:37]([O:40][CH3:41])[N:38]=4)[N:33]=[CH:32][CH:31]=3)[N:26]=2)[CH2:22]1)[CH2:9][C:10]1[CH:11]=[CH:12][C:13]2[S:18][CH2:17][C:16](=[O:19])[NH:15][C:14]=2[CH:20]=1)(C)(C)C>Cl.CCOCC>[CH3:41][O:40][C:37]1[N:38]=[C:39]2[C:34](=[CH:35][CH:36]=1)[N:33]=[CH:32][CH:31]=[C:30]2[N:25]1[CH:24]=[C:23]2[C:27]([CH2:28][CH2:29][CH:21]([N:8]([CH2:7][C:6]([OH:42])=[O:5])[CH2:9][C:10]3[CH:11]=[CH:12][C:13]4[S:18][CH2:17][C:16](=[O:19])[NH:15][C:14]=4[CH:20]=3)[CH2:22]2)=[N:26]1

Participants

4

Reactant 1

HCID 11948473HCID 11948473, compound

Product 1

HCID 11948474HCID 11948474, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of [[2-(6-methoxy-[1,5]naphthyridin-4-yl)-4,5,6,7-tetrahydro-2H-indazol-5-yl]-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]-acetic acid tert-butyl ester (5 mg, 0.009 mmol) in 4 M HCl in Et2O (1 mL) was stirred at RT for 3 h. The reaction mixture was concentrated to provide 4.5 mg (100%) of the title compound. MS (ESI): exact mass calculated for C27H26N6O4S, 530.17; m/z found, 531.08 [M+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-d768f3bc88024e23b39d6e47f527b2fd
Source dataset
uspto-grants-2012_08
Patent number
US08242275B2

Reaction notes

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