Acetic Acid → HCID 75985013, compound

HRID 885780Notes

Reaction equation

HRID 885780 reaction equation
Br[CH2:2][C:3]([O:11][CH3:12])=[CH:4][C:5](=[O:10])[C:6]([Cl:9])([Cl:8])[Cl:7].[C:13]([O-:16])(=[O:15])[CH3:14].[K+].C(O)(=O)C>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(#N)C>[C:13]([O:16][CH2:2][C:3]([O:11][CH3:12])=[CH:4][C:5](=[O:10])[C:6]([Cl:9])([Cl:8])[Cl:7])(=[O:15])[CH3:14]

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 517044Potassium AcetateHCID 72820289HCID 72820289, compound

Product 1

HCID 75985013HCID 75985013, compound

Reagents, catalysts & solvents 2

HCID 74236Tetrabutylammonium BromideCatalystHCID 6342AcetonitrileSolvent

Procedure

29.6 g (0.1 mol) of 5-bromo-1,1,1-trichloro-4-methoxypent-3-en-2-one, 17 g of potassium acetate, 5 g of tetrabutylammonium bromide and 8 g of acetic acid were stirred in 300 ml of acetonitrile at 40° C. for 16 h. The mixture was concentrated under reduced pressure, and water was added to the residue. The product was extracted with ethyl acetate, the organic phase was washed with water and the solvent was removed fully under reduced pressure.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure, and water
  2. additionwas added to the residue
  3. extractionThe product was extracted with ethyl acetate
  4. washthe organic phase was washed with water
  5. customthe solvent was removed fully under reduced pressure

Sources & evidence

ORD record
ord-6997653a992545bf94ed3d2618fd6555
Source dataset
uspto-grants-2012_08
Patent number
US08242313B2

Reaction notes

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