Oxalyl chloride → HCID 58320704, compound

HRID 885783Notes

Reaction equation

HRID 885783 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH2:10][C:9](O)([C:11]([Cl:14])([Cl:13])[Cl:12])[N:8]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][N:17]=2)[N:7]=1)(=[O:3])[CH3:2].C(Cl)(=O)C(Cl)=O>C(OC)(C)(C)C>[C:1]([O:4][CH2:5][C:6]1[CH:10]=[C:9]([C:11]([Cl:12])([Cl:13])[Cl:14])[N:8]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][N:17]=2)[N:7]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 53235559HCID 53235559, compound

Product 1

HCID 58320704HCID 58320704, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Conditions

Temperature
25 °C

Procedure

38.7 g of [1-(3-chloropyridin-2-yl)-5-hydroxy-5-(trichloromethyl)-4,5-dihydro-1H-pyrazol-3-yl]-methyl acetate were dissolved in 200 ml of methyl tert-butyl ether, and 12.6 g of oxalyl chloride were added dropwise within 2 h (vigorous evolution of gas). The mixture was stirred at 25° C. for a further 5 h and concentrated completely under reduced pressure.

Workup

  1. concentrationconcentrated completely under reduced pressure

Sources & evidence

ORD record
ord-0232653f0e534f258305e688136346ea
Source dataset
uspto-grants-2012_08
Patent number
US08242313B2

Reaction notes

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