Phthalimide potassium salt → HCID 25183527, compound

HRID 885794Notes

Reaction equation

HRID 885794 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:13][C:12]([C:18]3[CH:23]=[C:22]([Cl:24])[CH:21]=[C:20]([Cl:25])[CH:19]=3)([C:14]([F:17])([F:16])[F:15])[O:11][N:10]=2)=[CH:5][CH:4]=1.[C:26]1(=[O:36])[NH:30][C:29](=[O:31])[C:28]2=[CH:32][CH:33]=[CH:34][CH:35]=[C:27]12.[K]>CN(C)C=O.C(OCC)(=O)C>[Cl:25][C:20]1[CH:19]=[C:18]([C:12]2([C:14]([F:17])([F:15])[F:16])[O:11][N:10]=[C:9]([C:6]3[CH:5]=[CH:4][C:3]([CH2:2][N:30]4[C:29](=[O:31])[C:28]5=[CH:32][CH:33]=[CH:34][CH:35]=[C:27]5[C:26]4=[O:36])=[CH:8][CH:7]=3)[CH2:13]2)[CH:23]=[C:22]([Cl:24])[CH:21]=1

Participants

5

Reactant 2

HCID 24194345Phthalimide potassium saltHCID 86631548HCID 86631548, compound

Product 1

HCID 25183527HCID 25183527, compoundYield 99.6%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

In a solution of 1.20 g of 3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole in 20 mL of N,N-dimethylformamide, 0.54 g of potassium phthalimide was added and stirred at room temperature for 20 hours. After the completion of the reaction, the reaction mixture was diluted with 100 mL of ethyl acetate, washed with water (50 mL×3) and then dehydrated with and dried over saturated sodium chloride aqueous solution and anhydrous magnesium sulfate in that order, and the solvent was distilled off under reduced pressure to obtain 1.50 g of the aimed product as white crystal.

Workup

  1. customAfter the completion of the reaction
  2. washwashed with water (50 mL×3)
  3. dry with materialdried over saturated sodium chloride aqueous solution and anhydrous magnesium sulfate in that order
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-e5d1cb83b7db46da8ee6b4a7bf5bc360
Source dataset
uspto-grants-2012_08
Patent number
US08242283B2

Reaction notes

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