反应详情

温度

70 °C

In a solution of 13.7 g of 3-(3-chloro-4-methylphenyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole in 100 mL of 1,2-dichloroethane, 6.6 g of N-bromosuccinimide and 0.1 g of α,α′-azobisisobutyronitrile were added, and stirred at 70° C. for 3 hours. After the completion of the reaction, the reaction mixture was left and cooled to room temperature, washed with water (70 mL×2), and dehydrated with and dried over saturated sodium chloride aqueous solution and anhydrous sodium sulfate in that order, and then the solvent was distilled off under reduced pressure. The residual solid was washed with diisopropyl ether to obtain 12.1 g of the aimed product as pale yellow crystal.

1. customAfter the completion of the reaction
2. waitthe reaction mixture was left
3. temperaturecooled to room temperature
4. washwashed with water (70 mL×2)
5. dry with materialdried over saturated sodium chloride aqueous solution and anhydrous sodium sulfate in that order
6. distillationthe solvent was distilled off under reduced pressure
7. washThe residual solid was washed with diisopropyl ether