1-Methylpiperazine → 1-(6-Chloropyridin-3-yl)-4-methylpiperazine

HRID 885951Notes

Reaction equation

HRID 885951 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[Cl:8][C:5]1[N:6]=[CH:7][C:2]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 27344145-Bromo-2-chloropyridine

Product 1

HCID 753557481-(6-Chloropyridin-3-yl)-4-methylpiperazine

Procedure

The title compound was prepared from 5-bromo-2-chloropyridine and 1-methylpiperazine according to Method BG and was isolated as a brown oil (27%). LCMS (ES+) 212.0 (M+H)+, RT 1.97 minutes (70% purity) (Method 2).

Sources & evidence

ORD record
ord-ca10648444af454897bc959cea819a07
Source dataset
uspto-grants-2012_08
Patent number
US08242116B2

Reaction notes

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