Hydrogen chloride-ethyl acetate → HCID 68579793, compound

HRID 886896Notes

Reaction equation

HRID 886896 reaction equation
[N:1]1([C:7]2[C:17]3[O:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[ClH:31].[N:1]1([C:7]2[C:17]3[O:16][CH2:15][CH2:14][NH:13][CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578121HCID 68578121, compound

Product 1

HCID 68579793HCID 68579793, compoundYield 78.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl 9-(piperidin-1-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (130 mg, 0.391 mmol) and 4N hydrogen chloride-ethyl acetate (4 ml) in ethyl acetate (1 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (93.6 mg, 78.7%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-bba0bf1c02ab4e2c964c98632ee7bd9c
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

Loading…