Hydrogen chloride-ethyl acetate → HCID 86640605, compound

HRID 886920Notes

Reaction equation

HRID 886920 reaction equation
CC(OC([N:11]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=2[O:14][CH2:13][CH2:12]1)=O)CCCCC.C(O[CH2:26][CH3:27])(=O)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[CH3:17][CH:16]([CH:13]1[CH2:12][NH:11][CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=2[O:14]1)[CH2:15][CH2:21][CH2:20][CH2:26][CH3:27]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86640607HCID 86640607, compound

Product 1

HCID 86640605HCID 86640605, compoundYield 29.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-bicyclo[2.2.1]hepta-2-yl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (100 mg, 0.292 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (2 ml) was stirred at room temperature for 0.5 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (24.0 mg, 29.4%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-e7ee65928d4740daa0e7eac637c89f24
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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