Hydrogen chloride-ethyl acetate → HCID 68580146, compound

HRID 886922Notes

Reaction equation

HRID 886922 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[C:17]3[O:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:25])[O:4][N:3]=1.C(OCC)(=O)C.[ClH:32]>C(OCC)(=O)C>[ClH:32].[CH3:1][C:2]1[C:6]([C:7]2[C:17]3[O:16][CH2:15][CH2:14][NH:13][CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:25])[O:4][N:3]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68580291HCID 68580291, compound

Product 1

HCID 68580146HCID 68580146, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-(3,5-dimethylisoxazol-4-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (120 mg, 0.348 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (2 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (67.4 mg, 69.0%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-d22b5c6a93df44129dae1a2ed9f28bea
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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