Hydrogen chloride-ethyl acetate → HCID 68580168, compound

HRID 886924Notes

Reaction equation

HRID 886924 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:18]3[O:17][CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][C:12]=3[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C(OCC)(=O)C.[ClH:32]>C(OCC)(=O)C>[ClH:32].[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:18]3[O:17][CH2:16][CH2:15][NH:14][CH2:13][C:12]=3[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68580594HCID 68580594, compound

Product 1

HCID 68580168HCID 68580168, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-(3-fluorophenyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (390 mg, 1.14 mmol), ethyl acetate (4 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (309 mg, 97.2%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-dc8b8b0e1d8e4190aa24f6a1176e944d
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

Loading…