Hydrogen chloride-ethyl acetate → HCID 68578461, compound

HRID 886960Notes

Reaction equation

HRID 886960 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[C:17]3[O:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH2:5][CH2:4][O:3]1.C(OCC)(=O)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[O:16]1[C:17]2[C:7]([N:6]3[CH2:5][CH2:4][O:3][C:2]3=[O:1])=[CH:8][CH:9]=[CH:10][C:11]=2[CH2:12][NH:13][CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578315HCID 68578315, compound

Product 1

HCID 68578461HCID 68578461, compoundYield 63.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-(2-oxo-1,3-oxazolidin-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (230 mg, 0.688 mmol), ethyl acetate (3 ml) and 4N hydrogen chloride-ethyl acetate solution (3 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (118 mg, 63.4%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-dcdc74446ec84f8e8a87f829e259c37e
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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