Hydrogen chloride-ethyl acetate → HCID 68578312, compound

HRID 886963Notes

Reaction equation

HRID 886963 reaction equation
[CH:1]1([C:5]2[C:15]3[O:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C:9]=3[CH:8]=[CH:7][CH:6]=2)[CH2:4][CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:29]>C(OCC)(=O)C>[ClH:29].[CH:1]1([C:5]2[C:15]3[O:14][CH2:13][CH2:12][NH:11][CH2:10][C:9]=3[CH:8]=[CH:7][CH:6]=2)[CH2:2][CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68579806HCID 68579806, compound

Product 1

HCID 68578312HCID 68578312, compoundYield 79.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-cyclobutyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (40.0 mg, 0.132 mmol), ethyl acetate (2 ml) and 4N hydrogen chloride-ethyl acetate solution (2 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (25.0 mg, 79.1%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-cdfb5671d2804f8297d6daaf6bf093d0
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

Loading…