1,2-Dichloroethane → HCID 22249396, compound

HRID 887528Notes

Reaction equation

HRID 887528 reaction equation
[CH3:1][C:2]1([CH3:14])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][CH2:3]1.C1[CH:20]=[N:19][C:18]2N(O)N=NC=2C=1.[CH2:25](Cl)[CH2:26]Cl.CN(C=[O:33])C>C(Cl)Cl>[CH3:18][N:19]([CH3:20])[CH2:25][C:26]([N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=2)[C:2]([CH3:14])([CH3:1])[CH2:3]1)=[O:33]

Participants

6

Reactant 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 181649HOAtHCID 219594663,3-Dimethyl-6-nitroindoline

Product 1

HCID 22249396HCID 22249396, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3,3-Dimethyl-6-nitro-2,3-dihydro-1H-indole (5 g) was dissolved in DMF (100 ml) and HOAt (3.89 g) dimethylamino-acetic acid (5.83 g) and EDC (3.89 g) were added. The reaction was stirred overnight. The mixture was diluted with CH2Cl2 (1 L) and washed with sat'd NaHCO3 (3×200 ml). The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography (SiO2, EtOAc to 5% MeOH/EtOAc) to afford the title compound.

Workup

  1. washwashed with sat'd NaHCO3 (3×200 ml)
  2. washThe organic layer was washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by flash chromatography (SiO2, EtOAc to 5% MeOH/EtOAc)

Sources & evidence

ORD record
ord-4cc5b36c4f1c44329e518ff7d251c062
Source dataset
uspto-grants-2012_08
Patent number
US08247430B2

Reaction notes

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