HRID887685

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID892769

未命名化合物

HCID3085099

2-Hydrazino-delta-2-imidazoline hydrobromide

C3H9BrN4

结构：COC1=CC(=O)c2c(O)c3c(c(O)c2C1=O)C(=O)[C@]1(CCc2cc4cc(C=O)[nH]c(=O)c4c(O)c21)C3=O

HCID178493334

未命名化合物

PRODUCTS

生成物

结构：COC1=CC(=O)c2c(O)c3c(c(O)c2C1=O)C(=O)C1(CCc2cc4cc(C=NNC5=NCCN5)[nH]c(=O)c4c(O)c21)C3=O

HCID178493327

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

Five (5.00) mg (9.42 μmol) fredericamycin aldehyde (4) are dissolved in 500 μl DMF and 25 μl trifluoracetic acid. At room temperature, 2.05 mg (11.3 μmol) 2-hydrazino-2-imidazolin hydrobromide is added. After stirring for 4.5 h at room temperature, 1 equivalent each of Wang aldehyde resin and sulfonohydrazide resin are added and stirred for 2 h. Separation of the resin by filtration and concentration of the reaction solution at high vacuum.

WORKUP

后处理

stirringstirred for 2 h
customSeparation of the resin
filtrationby filtration and concentration of the reaction solution at high vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d2ce06a2d1c54918b99a142272e17fa2
来源数据集: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08247424B2
来源说明: uspto-grants-2012_08

反应 SMILES

[OH:1][C:2]1[C:11]2[C:10](=[O:12])[C:9]([O:13][CH3:14])=[CH:8][C:7](=[O:15])[C:6]=2[C:5]([OH:16])=[C:4]2[C:17](=[O:37])[C@:18]3([C:32]4[C:31]([OH:33])=[C:30]5[C:25]([CH:26]=[C:27]([CH:35]=O)[NH:28][C:29]5=[O:34])=[CH:24][C:23]=4[CH2:22][CH2:21]3)[C:19](=[O:20])[C:3]=12.Br.[NH:39]([C:41]1[NH:42][CH2:43][CH2:44][N:45]=1)[NH2:40].C1C=CC(CNC(CN2C3C(=CC=CC=3)C(C=O)=C2)=O)=CC=1>CN(C=O)C.FC(F)(F)C(O)=O>[NH:45]1[CH2:44][CH2:43][N:42]=[C:41]1[NH:39][N:40]=[CH:35][C:27]1[NH:28][C:29](=[O:34])[C:30]2[C:25]([CH:26]=1)=[CH:24][C:23]1[CH2:22][CH2:21][C:18]3([C:17](=[O:37])[C:4]4=[C:5]([OH:16])[C:6]5[C:7](=[O:15])[CH:8]=[C:9]([O:13][CH3:14])[C:10](=[O:12])[C:11]=5[C:2]([OH:1])=[C:3]4[C:19]3=[O:20])[C:32]=1[C:31]=2[OH:33]