反应详情

5-Amino-2-chloro-4-methylpyridine (1.35 g) was dissolved in DMF (20 mL), N-iodosuccinimide (2.59 g) was added and the reaction mixture was stirred at room temperature for 12 hours. Ethyl acetate was added and the organic layer was washed 3× with water, washed with brine, dried over MgSO4 and concentrated in vacuum. The residue was purified by column chromatography (silica 60, hexane/ethyl acetate=3:1, Rf=0.30) to afford 1.38 g of the title compound of the formula

1. washthe organic layer was washed 3× with water
2. washwashed with brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuum
5. customThe residue was purified by column chromatography (silica 60, hexane/ethyl acetate=3:1, Rf=0.30)