Hydrochloric Acid → 2-(8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridin-9-yl)ethanamine hydrochloride

HRID 887775Notes

Reaction equation

HRID 887775 reaction equation
[NH2:1][CH2:2][CH2:3][CH:4]1[C:8]2[C:9]3[N:10]([N:13]=[CH:14][C:15]=3C(OCC)=O)[CH:11]=[CH:12][C:7]=2[CH2:6][CH2:5]1.[ClH:21]>>[ClH:21].[CH:15]1[CH:14]=[N:13][N:10]2[CH:11]=[CH:12][C:7]3[CH2:6][CH2:5][CH:4]([CH2:3][CH2:2][NH2:1])[C:8]=3[C:9]=12

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59145841ethyl 9-(2-aminoethyl)-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate

Product 1

HCID 686989162-(8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridin-9-yl)ethanamine hydrochlorideYield 99%

Conditions

Temperature
110 °C

Procedure

A mixture of ethyl 9-(2-aminoethyl)-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate (105 mg, 0.384 mmol) in 12M hydrochloric acid (4 mL) was stirred at 110° C. for 14 hr, and concentrated under reduced pressure to give the title compound (91.1 mg, yield 99%).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-1749d3fff6284c948d5d28fb15940750
Source dataset
uspto-grants-2012_08
Patent number
US08247429B2

Reaction notes

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