反应详情

To a mixture of ethyl 9-(2-aminoethyl)-2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate (50.0 mg, 0.174 mmol) and triethylamine (36.4 μL, 0.261 mmol) in tetrahydrofuran (2 mL) was added acetic anhydride (24.7 μL) under ice-cooling, and the mixture was stirred at room temperature for 30 min. Water (50 μL) was added, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (methanol/ethyl acetate=0/100→5/95) and recrystallization (diisopropyl ether) to give the title compound (32.1 mg, yield 56%).

1. temperaturecooling
2. customthe solvent was evaporated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (methanol/ethyl acetate=0/100→5/95) and recrystallization (diisopropyl ether)