N-(3-Aminopropyl)morpholine → HCID 68408153, compound

HRID 888039Notes

Reaction equation

HRID 888039 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4](F)[CH:3]=1.[NH2:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>CN(C)C(=O)C>[I:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[CH:3]=1

Participants

4

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 70235702-Fluoro-4-iodopyridine

Product 1

HCID 68408153HCID 68408153, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

A solution of 4-iodo-2-fluoropyridine (2.32 g, 10.00 mmol) and N-(3-aminopropyl)morpholine (4.2 ml, 26.00 mmol) in N,N-dimethylacetamide (30 ml) was heated to 100° C. for 20 hours before being concentrated in vacuo, to afford the crude title compound which was used without any further purification; Mass Spectrum: M+H+ 348.

Workup

  1. concentrationbefore being concentrated in vacuo

Sources & evidence

ORD record
ord-4d981b6e266d4f77807fa3c5f93608e4
Source dataset
uspto-grants-2012_08
Patent number
US08247562B2

Reaction notes

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