Hydrochloric Acid → 4-Aminomethyl-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one hydrochloride

HRID 888126Notes

Reaction equation

HRID 888126 reaction equation
[O:1]=[C:2]1[NH:12][C:5]2[N:6]=[CH:7][CH:8]=[C:9]([C:10]#[N:11])[C:4]=2[CH2:3]1.[ClH:13]>CCO.[Pd]>[ClH:13].[NH2:11][CH2:10][C:9]1[CH:8]=[CH:7][N:6]=[C:5]2[NH:12][C:2](=[O:1])[CH2:3][C:4]=12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 692637962-oxo-1H,2H,3H-pyrrolo[2,3-b]pyridine-4-carbonitrile

Product 1

HCID 692690594-Aminomethyl-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one hydrochloride

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Hydrogenation of 2-Oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (100 mg) was done using Pd/C (20 mg), HCl (37%, 0.3 mL) in EtOH (3 mL) to give 4-aminomethyl-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one hydrochloride.

Sources & evidence

ORD record
ord-9daf00d2886849808144e9814dad16c1
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

Loading…