Isonicotinic Acid → 1-(Pyridin-4-yl-[1,2,4]oxadiazol-3-yl)-piperazine dihydrochloride

HRID 888181Notes

Reaction equation

HRID 888181 reaction equation
[ClH:1].Cl.[C:3]1([C:9]2[O:13][N:12]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[N:10]=2)[CH:8]=[CH:7]C=[CH:5][CH:4]=1.C(O)(=O)C1C=C[N:24]=CC=1>>[ClH:1].[ClH:1].[N:24]1[CH:7]=[CH:8][C:3]([C:9]2[O:13][N:12]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[N:10]=2)=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 5922Isonicotinic AcidHCID 673331091-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperazine dihydrochloride

Product 1

HCID 673328801-(Pyridin-4-yl-[1,2,4]oxadiazol-3-yl)-piperazine dihydrochloride

Procedure

The title product was prepared following the procedure of Intermediate 11 (step a to d) but using isonicotinic acid in step c). The title compound was obtained as a solid. TLC-Chloroform/methanol (8/2): Rf=0.2. HPLC purity: 97%.

Workup

  1. customThe title product was prepared

Sources & evidence

ORD record
ord-4ce9bd4da96f4efa94714272ccb29753
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

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