反应详情

温度

70 °C

The mixture of 11.8 g indane (0.1 mol) and 10 ml 3-chloropropionyl chloride (0.12 mol) was added to suspension of 16 g AlCl3 (0.55 mol) in 100 ml CH2Cl2 at 0° C. After then reaction mixture was poured into ice and HCl, the organic layer was isolated; the aqueous one was extracted with CH2Cl2 (2*50 ml). The combined organic phase was washed by NaHCO3, dried over MgSO4 and evaporated. The residue was added carefully to conc. H2SO4 (100 ml), warmed to 70° C. and stirred after then 30 min at the same temperature. The mixture was cooled and poured into ice. Precipitate was filtered, washed by water and dried, to give 12.4 g of product (72%).

1. customAfter then reaction mixture
2. customthe organic layer was isolated
3. extractionthe aqueous one was extracted with CH2Cl2 (2*50 ml)
4. washThe combined organic phase was washed by NaHCO3
5. dry with materialdried over MgSO4
6. customevaporated
7. additionThe residue was added carefully to conc. H2SO4 (100 ml)
8. temperatureThe mixture was cooled
9. additionpoured into ice
10. filtrationPrecipitate was filtered
11. washwashed by water
12. customdried