Hydrochloric Acid → HCID 68498446, compound

HRID 888379Notes

Reaction equation

HRID 888379 reaction equation
[CH:1]1([C:4]2[N:5]([CH3:29])[C:6]([C:9]3[CH:10]=[C:11]([CH:19]=[C:20]([C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=4)[CH:21]=3)[C:12]([O:14]C(C)(C)C)=[O:13])=[N:7][N:8]=2)[CH2:3][CH2:2]1.FC(F)(F)C(O)=O.Cl>CO>[CH:1]1([C:4]2[N:5]([CH3:29])[C:6]([C:9]3[CH:10]=[C:11]([CH:19]=[C:20]([C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=4)[CH:21]=3)[C:12]([OH:14])=[O:13])=[N:7][N:8]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 68500854HCID 68500854, compound

Product 1

HCID 68498446HCID 68498446, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl 3-(5-cyclopropyl-4-methyl-4H-1,2,4-triazol-3-yl)-5-(5-methylpyridin-2-yl)benzoate (0.38 g, 0.97 mmol) in methyl alcohol (10 mL) was added trifluoroacetic acid (5.0 mL, 67.3 mmol) and hydrogen chloride (4.0 M in dioxane; 5.0 mL, 20.0 mmol). The reaction mixture was stirred at ambient temperature. After 18 h, the mixture was concentrated and dried under reduced pressure gave the hydrochloride salt of the title compound. MS 335.1 (M+1).

Workup

  1. concentrationthe mixture was concentrated
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-94a96b12dd0c4ecdb3c58c6a28e032a3
Source dataset
uspto-grants-2012_08
Patent number
US08247401B2

Reaction notes

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