Hydrochloric Acid → Sodium Chloride

HRID 888408Notes

Reaction equation

HRID 888408 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[C:16]([C:18]([CH3:20])=[CH2:19])[CH:17]=2)[C:11]([O:13]C)=[O:12])=[N:6][CH:7]=1.[OH-].[Na+:22].Cl>CO>[Cl-:1].[Na+:22].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[C:16]([C:18]([CH3:20])=[CH2:19])[CH:17]=2)[C:11]([OH:13])=[O:12])=[N:6][CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68497736Methyl 3-(5-chloropyridin-2-yl)-5-isopropenylbenzoate

Product 2

HCID 5234Sodium ChlorideHCID 685013473-(5-Chloropyridin-2-yl)-5-isopropenylbenzoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of methyl 3-(5-chloropyridin-2-yl)-5-isopropenylbenzoate (0.13 g, 0.46 mmol) in methanol (3.1 mL) was added 1 M aqueous sodium hydroxide (0.92 mL, 0.92 mmol) and the mixture was heated to 60° C. After 45 min, hydrochloric acid (76 uL, 092 mmol) was added and the mixture was concentrated to dryness gave the bis sodium chloride salt of the title compound. MS 274.0 (M+1).

Workup

  1. concentrationthe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-3b6c819b53874c38b6a7d7426d144e00
Source dataset
uspto-grants-2012_08
Patent number
US08247401B2

Reaction notes

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