反应详情

To a solution of tert-butyl 3-bromo-5-(2,2,2-trifluoro-1-hydroxyethyl)benzoate (8.8 g, 24.8 mmol) in dichloromethane (124 mL) was added Dess-MartinPeriodinane (15.8 g, 37.2 mmol). The mixture was stirred at ambient temperature. After 2 h, saturated NaHCO3 and saturated Na2SO3. The mixture was extracted with dichloromethane (3×). The combined organic extracts were washed with water (6×), brine, dried over sodium sulfate, filtered and concentrated.

1. extractionThe mixture was extracted with dichloromethane (3×)
2. washThe combined organic extracts were washed with water (6×), brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated