反应详情

To a solution of 1.0 g of 4,4,4-trifluoro-3-methylbutyl p-toluenesulfonate and 0.7 g of (3,3,3-trifluoropropylsulfonyl)acetonitrile in 50 ml of dimethyl sulfoxide was added 0.5 g of potassium carbonate at room temperature, and then stirred at the same temperature for 16 hours. To the reaction mixture was added 10% hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The obtained residue was subjected to silica gel chromatography to obtain 0.50 g of 6,6,6-trifluoro-5-methyl-2-(3,3,3-trifluoropropylsulfonyl)hexanenitrile (hereinafter referred to as the present compound (10)).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with a saturated sodium chloride aqueous solution
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure