反应详情

温度

85 °C

A mixture of 1,3-dipropyl-8-{1-[2-(3-trifluoromethyl-phenyl)-cyclopropylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.55 g, 0.087 mmol), 2 N HCl (2 ml), ethanol (3 ml) were heated at 85° C. for 3 hours. The mixture was cooled to 10-15° C. and solid material was separated. It was filtered off and washed with water (1 ml), diethyl ether (1 ml) to obtain the title compound (0.016 g, 37

1. temperatureThe mixture was cooled to 10-15° C.
2. customsolid material was separated
3. filtrationIt was filtered off
4. washwashed with water (1 ml), diethyl ether (1 ml)