Hydrochloric Acid → HCID 57988765, compound

HRID 889024Notes

Reaction equation

HRID 889024 reaction equation
[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[N:10](COCC[Si](C)(C)C)[C:9]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][CH:28]4[CH2:30][CH:29]4[C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:40])([F:39])[F:38])[CH:32]=4)[CH:26]=3)=[N:8][C:7]=2[N:6]([CH2:41][CH2:42][CH3:43])[C:5]1=[O:44])[CH2:2][CH3:3].Cl>C(O)C>[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[NH:10][C:9]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][CH:28]4[CH2:30][CH:29]4[C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:39])([F:38])[F:40])[CH:32]=4)[CH:26]=3)=[N:8][C:7]=2[N:6]([CH2:41][CH2:42][CH3:43])[C:5]1=[O:44])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57988779HCID 57988779, compound

Product 1

HCID 57988765HCID 57988765, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 1,3-dipropyl-8-{1-[2-(3-trifluoromethyl-phenyl)-cyclopropylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.55 g, 0.087 mmol), 2 N HCl (2 ml), ethanol (3 ml) were heated at 85° C. for 3 hours. The mixture was cooled to 10-15° C. and solid material was separated. It was filtered off and washed with water (1 ml), diethyl ether (1 ml) to obtain the title compound (0.016 g, 37

Workup

  1. temperatureThe mixture was cooled to 10-15° C.
  2. customsolid material was separated
  3. filtrationIt was filtered off
  4. washwashed with water (1 ml), diethyl ether (1 ml)

Sources & evidence

ORD record
ord-69c6c36a1cc54c55b48abb8771fd1e05
Source dataset
uspto-grants-2012_08
Patent number
US08252797B2

Reaction notes

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