3,5-Dimethylpyrazole → HCID 131729911, compound

HRID 889079Notes

Reaction equation

HRID 889079 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH3:15])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:16][C:17]1[CH:21]=[C:20]([CH3:22])[NH:19][N:18]=1>C(#N)C>[ClH:1].[CH3:16][C:17]1[CH:21]=[C:20]([CH3:22])[N:19]([C:2]2[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH3:15])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[N:18]=1

Participants

4

Reactant 2

HCID 62103,5-DimethylpyrazoleHCID 22692581HCID 22692581, compound

Product 1

HCID 131729911HCID 131729911, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
170 °C

Procedure

(2-Chloro-quinazolin-4-yl)-propylamine (450 mg, 2.03 mmol) was dissolved in acetonitrile (7.5 mL) and 3,5-dimethylpyrazole (215 mg, 2.23 mmol) was added. The mixture was heated in a microwave oven at 170° C. for 20 minutes. Filtration gave [2-(3,5-dimethylpyrazol-1-yl)-quinazolin-4-yl]-propylamine, hydrochloride (290 mg, 51%) as a pale red crystalline compound. Mp. 208° C.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-b94e812095ac4382b7463955f7cb5ebe
Source dataset
uspto-grants-2012_08
Patent number
US08252806B2

Reaction notes

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