Cyclohexylamine → HCID 131729930, compound

HRID 889099Notes

Reaction equation

HRID 889099 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH:13]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.[CH:20]([C:23]1[CH:27]=[C:26]([CH:28]([CH3:30])[CH3:29])[NH:25][N:24]=1)([CH3:22])[CH3:21].[H-].[Na+]>C(N(CC)CC)C>[ClH:1].[CH:13]1([NH:19][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([N:24]3[C:23]([CH:20]([CH3:21])[CH3:22])=[CH:27][C:26]([CH:28]([CH3:30])[CH3:29])=[N:25]3)[N:11]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

6

Reactant 4

HCID 7965CyclohexylamineHCID 24758Sodium hydrideHCID 2528862,4-DichloroquinazolineHCID 52552293,5-Diisopropylpyrazole

Product 1

HCID 131729930HCID 131729930, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Was prepared according to Method A from 2,4-dichloroquinazoline, cyclohexylamine and 3,5-diisopropylpyrazole with sodium hydride as base instead of triethylamine. Mp. 83.4-85.3° C.

Workup

  1. customWas prepared

Sources & evidence

ORD record
ord-a0c33c90c6da465c99240f0819c085f3
Source dataset
uspto-grants-2012_08
Patent number
US08252806B2

Reaction notes

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