反应详情

After dissolving 6,7,8,9-tetrahydropyrido[1,2-a][1,3,5]triazine-2,4-dione (CAS 133365-43-2) (195 mg) and epibromohydrin (321 mg) in N,N-dimethylformamide (1 ml), sodium hydride (60% in oil) (52 mg) was added and the mixture was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure, and the residue was purified by NH silica gel column chromatography. The title compound (189 mg) was thus obtained.

1. additionwas added
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe residue was purified by NH silica gel column chromatography