Hydrochloric Acid → HCID 59186979, compound

HRID 889313Notes

Reaction equation

HRID 889313 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[C:13](=[O:14])[C:12]([C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)=[CH:11][NH:10]2)[CH:4]=1)#N.[OH-:21].[Na+].Cl.[OH2:24]>C(O)C>[O:14]=[C:13]1[N:9]([C:5]2[CH:4]=[C:3]([CH:8]=[CH:7][N:6]=2)[C:1]([OH:24])=[O:21])[NH:10][CH:11]=[C:12]1[C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68704935HCID 68704935, compound

Product 1

HCID 59186979HCID 59186979, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

200 mg (760 μmol) of the compound from Example 29 are suspended in a mixture of 6 ml ethanol and 4 ml water, 0.6 ml 50% strength sodium hydroxide solution are added and the mixture is heated under reflux for 1 h. After cooling, a weakly acid pH is established with 1 M hydrochloric acid and the precipitate is filtered off with suction, washed with water and dried.

Workup

  1. additionare added
  2. temperaturethe mixture is heated
  3. temperatureunder reflux for 1 h
  4. temperatureAfter cooling
  5. filtrationthe precipitate is filtered off with suction
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-7b09a0412e164788a7731f9a3ffe1759
Source dataset
uspto-grants-2012_08
Patent number
US08252817B2

Reaction notes

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