Lithium Hydroxide → HCID 53390610, compound

HRID 889394Notes

Reaction equation

HRID 889394 reaction equation
C[O:2][C:3](=[O:38])[C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([O:11][CH2:12][CH:13]([C:20]2[N:21]([C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[N:22]=[C:23]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][C:24]=23)[CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:6]([CH3:37])[CH:5]=1.[OH-].[Li+]>C1COCC1.CO>[Cl:36][C:33]1[CH:34]=[CH:35][C:30]([N:21]2[C:20]([CH:13]([CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[CH2:12][O:11][C:7]3[C:8]([CH3:10])=[CH:9][C:4]([C:3]([OH:38])=[O:2])=[CH:5][C:6]=3[CH3:37])=[C:24]3[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:23]3=[N:22]2)=[CH:31][CH:32]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67387356HCID 67387356, compound

Product 1

HCID 53390610HCID 53390610, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 2, 4-{2-[2-(4-chloro-phenyl)-2,4,5,6,7,8-hexahydro-cycloheptapyrazol-3-yl]-2-cyclohexyl-ethoxy}-3,5-dimethyl-benzoic acid methyl ester was hydrolysed using aqueous lithium hydroxide solution in THF and MeOH to give the title compound as off-white solid. MS: m/e=507.2 [M+H+].

Sources & evidence

ORD record
ord-932416d1303541d1bbcd068580275b11
Source dataset
uspto-grants-2012_08
Patent number
US08252826B2

Reaction notes

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