反应详情

Add methyl 2-chloro-5-[(2,2-dimethylpropanoylamino)methyl]benzoate (1.05 kg, 3.7 mol), 1,4-dioxane (5.25 L) and water (3.15 L) together and then add lithium hydroxide (407.8 g, 9.6 mol). Stir the resulting suspension at room temperature for one hour. Acidify the mixture to pH 1 with 5 N aqueous HCl in a dropwise fashion at a rate such that the internal temperature does not exceed 30° C. Concentrate the solution to remove approximately 6 L of solvent, and cool the resulting suspension to 10° C. Filter, wash the resulting solid material with water (8 L), and allow to dry on the sinter for 3 h. Collect the solid, and dry the material in a vacuum oven at 40° C. for 48 h to give the title compound as a free-flowing white solid (775 g, 77.7%). MS (m/z) (35Cl/37Cl) 270/272 (M+1).

1. customdoes not exceed 30° C
2. concentrationConcentrate the solution
3. customto remove approximately 6 L of solvent
4. temperaturecool the resulting suspension to 10° C
5. filtrationFilter
6. washwash the resulting solid material with water (8 L)
7. customto dry on the sinter for 3 h
8. customCollect the solid
9. customdry the material in a vacuum oven at 40° C. for 48 h